Evaluation of loading parameters for murine axial tibial loading: Stimulating cortical bone formation while reducing loading duration
نویسندگان
چکیده
منابع مشابه
Knee loading stimulates cortical bone formation in murine femurs
BACKGROUND Bone alters its architecture and mass in response to the mechanical environment, and thus varying loading modalities have been examined for studying load-driven bone formation. The current study aimed to evaluate the anabolic effects of knee loading on diaphyseal cortical bone in the femur. METHODS Using a custom-made piezoelectric loader, 0.5-N loads were laterally applied to the ...
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The increasing incidence of osteoporosis worldwide requires anabolic treatments that are safe, effective, and, critically, inexpensive given the prevailing overburdened health care systems. While vigorous skeletal loading is anabolic and holds promise, deficits in mechanotransduction accrued with age markedly diminish the efficacy of readily complied, exercise-based strategies to combat osteopo...
متن کاملLong-Term Axial Loading Studies
born on the 15 of October, 1986 in Amsterdam. After graduating high school (Bilingual VWO, Berlage Lyceum, Amsterdam, cum laude) in 2005, he studied medicine at the Vrije Universiteit in Amsterdam. During his studies in 2008, he became involved in spine research through a one-year research internship within the PhD project of dr. R.J. Kroeze, “Adipose stem cells on a biodegradable polymer for s...
متن کاملTibial Loading Increases Osteogenic Gene Expression and Cortical Bone Volume in Mature and Middle-Aged Mice
There are conflicting data on whether age reduces the response of the skeleton to mechanical stimuli. We examined this question in female BALB/c mice of different ages, ranging from young to middle-aged (2, 4, 7, 12 months). We first assessed markers of bone turnover in control (non-loaded) mice. Serum osteocalcin and CTX declined significantly from 2 to 4 months (p<0.001). There were similar a...
متن کاملPredicting cortical bone adaptation to axial loading in the mouse tibia
The development of predictive mathematical models can contribute to a deeper understanding of the specific stages of bone mechanobiology and the process by which bone adapts to mechanical forces. The objective of this work was to predict, with spatial accuracy, cortical bone adaptation to mechanical load, in order to better understand the mechanical cues that might be driving adaptation. The ax...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2017
ISSN: 0736-0266
DOI: 10.1002/jor.23727